Anandam Anandamaye is a comedy about the lives and misfortunes of three men and their families. Anand Rao is a selfish man who only thinks about his happiness and never about others. Hanumanthu and Subbarao are his neighbors who get tired of Anand Rao taking advantage of them but are too timid to do anything about it. Anand Rao keeps having these strange accidents which makes his wife believe that his luck is tainted so, she forces him to go see an astrologer. The astrologer predicts his future and tells Anand Rao that he has only a month to live. He advises him to repent and do good to all the people whom he’s ever done wrong. So, Anand Rao sets out to right his wrongs with the help of his neighbors, Hanumanthu and Subbarao. He starts behaving very kindly with everyone and completely changes his attitude. The show is all about the three couples and their hilarious misadventures.